Abstract
Maximizing peak bone mass in childhood is relevant to optimizing bone health in later
life, so the study of the skeleton in children in health and disease is important.
Dual-energy X-ray absorptiometry (DXA) is the most widely used clinical tool for the
assessment of bone status in children. Technological developments in DXA enable vertebral
fracture assessment at much lower ionizing radiation doses than spinal radiographs.
Quantitative computed tomography remains predominantly a research tool but has some
advantages over DXA in not being size dependent. High-resolution peripheral computed
tomography measures trabecular and cortical bone microstructure but is technically
challenging, particularly in children, and not widely available, so it is unlikely
to be used in clinical practice. Other quantitative techniques (quantitative magnetic
resonance imaging, digital X-ray absorptiometry, quantitative ultrasound) have been
applied in children but remain research applications, and they are only covered briefly
in this review.
Keywords
children - bone densitometry - dual-energy X-ray absorptiometry - quantitative computed
tomography - vertebral fracture